HOXA5 INHIBITS THE PROLIFERATION OF EXTRAHEPATIC CHOLANGIOCARCINOMA CELLS BY ENHANCING MXD1 EXPRESSION AND ACTIVATING THE P53 PATHWAY

Abstract Homeobox A5 (HOXA5) is a transcription factor in mammalian and can regulate cell differentiation, proliferation, and apoptosis as well as tumorigenesis.However, little is known on whether and how HOXA5 can regulate the malignant behaviors of cholangiocarcinoma.The methylation levels of HOXA5 were evaluated by methylation microarray and bis

Windows are responsible for significant amounts of energy loss through typical building envelopes.There have been multiple studies on heat loss through the glazing unit and frame system.This study presents an experimental investigation of a window unit and focuses specifically on the conductance between the structural elements and the frame system